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Abstract <p>To reveal new functions of pannexin 1 in the mouse nervous system, cell types with the most pronounced expression of the gene encoding this protein were identified by bioinformatic analysis. It turned out that sensory neurons PSNP3 and PSNP6 of the dorsal root ganglia have the highest expression levels of <i>Panx1</i>, as well as high expression of purinoreceptor <i>p2rx3</i>, and other genes associated with the perception of pain and skin itch. The scratch reflex induced by compound 48/80 was suppressed in <i>Panx1</i> knockout mice compared to wild-type mice, confirming the involvement of <i>Panx1</i> in the purinergic regulation of sensory nerve fibers responsible for itch perception.</p>

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Bioinformatic and Behavioral Analysis of Pannexin 1 Involvement in Cutaneous Perception in Mice

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • O. O. Kiryukhina,
  • O. S. Tarasova,
  • Yu. V. Panchin

摘要

Abstract

To reveal new functions of pannexin 1 in the mouse nervous system, cell types with the most pronounced expression of the gene encoding this protein were identified by bioinformatic analysis. It turned out that sensory neurons PSNP3 and PSNP6 of the dorsal root ganglia have the highest expression levels of Panx1, as well as high expression of purinoreceptor p2rx3, and other genes associated with the perception of pain and skin itch. The scratch reflex induced by compound 48/80 was suppressed in Panx1 knockout mice compared to wild-type mice, confirming the involvement of Panx1 in the purinergic regulation of sensory nerve fibers responsible for itch perception.