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<p>It is shown that the complex of phlorotannins isolated from the marine brown alga <i>Sargassum pallidum</i> protects the pool of the oxidized form of NAD<sup>+</sup>–NADP<sup>+</sup> from depletion during an acute alcohol impact. Restoration of the NAD<sup>+</sup>/NADH ratio provided preservation of the redox potential in liver, necessary level of oxidized forms of metabolites of lactate dehydrogenase and glycerol-3-phosphate dehydrogenase shuttle cycles for maintenance of reactions of aerobic glycolysis and gluconeogenesis, regulation of the pentose phosphate cycle, promoted prevention of tissue hypoxia and normalization of the blood glucose level. This provides a basis for recommending the use of phlorotannin complexes as a prophylactic agent to attenuate the toxic effects of ethanol.</p>

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Prevention of Carbohydrate Metabolism Disorders in Rats by the Phlorotannins Complex of the Marine Brown Alga Sargassum pallidum under an Acute Alcohol Impact

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • V. G. Sprygin,
  • S. E. Fomenko,
  • N. F. Kushnerova

摘要

It is shown that the complex of phlorotannins isolated from the marine brown alga Sargassum pallidum protects the pool of the oxidized form of NAD+–NADP+ from depletion during an acute alcohol impact. Restoration of the NAD+/NADH ratio provided preservation of the redox potential in liver, necessary level of oxidized forms of metabolites of lactate dehydrogenase and glycerol-3-phosphate dehydrogenase shuttle cycles for maintenance of reactions of aerobic glycolysis and gluconeogenesis, regulation of the pentose phosphate cycle, promoted prevention of tissue hypoxia and normalization of the blood glucose level. This provides a basis for recommending the use of phlorotannin complexes as a prophylactic agent to attenuate the toxic effects of ethanol.