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Abstract <p>Current study was purposed to reveal the cytotoxic, apoptotic, antimicrobial and antioxidant potentials of oil extracted from <i>Dictyota dichotoma</i> (Hudson) J.V. Lamouroux 1809 collected from Antalya coast of Turkiye. <i>Dictyota dichotoma</i> oil showed better cytotoxic activity towards two different adenocarcinoma cell lines (Caco-2 (8.83 μg/mL) and LnCap (10.86 μg/mL)) compared to HEK293 cells (non-cancerous). Annexin V/PI staining and <i>q</i>PCR studies revealed that oil caused induction of apoptosis. <i>Dictyota dichotoma</i> oil inhibited the growth of <i>Aspergillus niger</i> ATCC 16404 and <i>Enterococcus faecalis</i> ATCC 29212. Nevertheless, the lower antioxidant activity of <i>Dictyota dichotoma</i> oil was determined compared with trolox standard for both DPPH and ABTS assays (4.8 fold less). In conclusion, <i>Dictyota dichotoma</i> oil has a promising potential in medical usage.</p>

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Cytotoxicity, Apoptotic, Antioxidant and Antimicrobial Activity of Dictyota dichotoma (Hudson) J.V. Lamouroux 1809 Collected from Antalya Coast, Turkiye

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Sevki Arslan,
  • Amine Hafis Abdelsalam,
  • Aslıhan Kurt Kızıldoğan,
  • Çiğdem Otur,
  • Metin Konuş,
  • Doğan Çetin,
  • Ceylan Fidan Babat,
  • Can Yılmaz,
  • Serpil Oğuztüzün,
  • Selin Sayın,
  • Mehmet Naz,
  • Emine Şükran Okudan

摘要

Abstract

Current study was purposed to reveal the cytotoxic, apoptotic, antimicrobial and antioxidant potentials of oil extracted from Dictyota dichotoma (Hudson) J.V. Lamouroux 1809 collected from Antalya coast of Turkiye. Dictyota dichotoma oil showed better cytotoxic activity towards two different adenocarcinoma cell lines (Caco-2 (8.83 μg/mL) and LnCap (10.86 μg/mL)) compared to HEK293 cells (non-cancerous). Annexin V/PI staining and qPCR studies revealed that oil caused induction of apoptosis. Dictyota dichotoma oil inhibited the growth of Aspergillus niger ATCC 16404 and Enterococcus faecalis ATCC 29212. Nevertheless, the lower antioxidant activity of Dictyota dichotoma oil was determined compared with trolox standard for both DPPH and ABTS assays (4.8 fold less). In conclusion, Dictyota dichotoma oil has a promising potential in medical usage.