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Abstract <p>Remdesivir, the first United States Food and Drug Administration-approved drug for emergency use for the treatment of SARS-Covid-19, is also considered a first-in-class medication. It is sold under the brand name Veklury. Remdesivir is a prodrug, and it allows intercellular transformation into GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analog inhibitor of viral RNA polymerase. The European Union also approved the use of Remdesivir for the treatment of Covid-19. Subsequently, the Food and Drug Administration approved the emergency use authorization of Remdesivir for Covid-19 in combination with Baricitinib. The current review presents various analytical methodologies for the determination of Remdesivir in bulk, in pharmaceutical formulations, and in biological samples, including ultraviolet-visible spectroscopy, fluorescence spectroscopy, liquid chromatography, and other hyphenated methods. This comprehensive summary should provide important information to the analyst interested in the development of analytical methods.</p>

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Analytical Methods for the Estimation of Remdesivir from its Various Matrices: A Review

  • 期刊论文

  • 发表日期：

    2025年10月22日

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  • Hardik L. Varu,
  • Mohammed Alqarni,
  • Mrunal A. Ambasana

摘要

Abstract

Remdesivir, the first United States Food and Drug Administration-approved drug for emergency use for the treatment of SARS-Covid-19, is also considered a first-in-class medication. It is sold under the brand name Veklury. Remdesivir is a prodrug, and it allows intercellular transformation into GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analog inhibitor of viral RNA polymerase. The European Union also approved the use of Remdesivir for the treatment of Covid-19. Subsequently, the Food and Drug Administration approved the emergency use authorization of Remdesivir for Covid-19 in combination with Baricitinib. The current review presents various analytical methodologies for the determination of Remdesivir in bulk, in pharmaceutical formulations, and in biological samples, including ultraviolet-visible spectroscopy, fluorescence spectroscopy, liquid chromatography, and other hyphenated methods. This comprehensive summary should provide important information to the analyst interested in the development of analytical methods.