Rapid Determination of Some Cephalosporins Using Immobilized para-Dimethylaminobenzaldehyde

Indicator papers with immobilized para-dimethylaminobenzaldehyde are proposed for the visual–colorimetric and colorimetric determination of antibacterial compounds of the cephalosporin group (cephalexin, cefuroxime, cefotaxime, ceftriaxone, cefazolin) using a smartphone camera. The effect of conditions and the type of the photorecording device is assessed. The accuracy of the developed rapid procedures is estimated using the added–found method; the procedures are characterized by the satisfactory reproducibility of results (RSD does not exceed 19%). An analysis of drugs—“Aksosef” tablets and “Cephalexin” capsules—is carried out; the found contents of cephalosporins are consistent with the declared ranges of their contents in the drugs.