Abstract <p>The paper deals with the fatigue strength of rods made of the Ti-10V-2Fe-3Al alloy with different carbon concentrations (0.031 and 0.063 wt %) under uniaxial cyclic loading. The alloy with 0.063 wt % C contains titanium carbide particles similar in morphology to those of the primary α phase with an average size of about 2–3 μm. It is experimentally found that the 3 million cycle fatigue strength of the alloy with titanium carbide particles is 1000 MPa. Analysis of fracture surfaces reveals that the specimens experience subsurface fracture near the fatigue strength, and fracture sites are represented by facets where particles of the primary α phase accumulate and cracks are initiated. It is experimentally shown and numerically confirmed that the presence of titanium carbide particles in the alloy does not affect its fatigue strength.</p>