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Abstract <p>Cartilage tissue engineering holds significant potential for regenerative medicine. In this study, we developed porous scaffolds composed of chitosan and graphene oxide (GO/CS) to enhance the properties and performance of scaffolds used for cartilage tissue regeneration. Findings of this study demonstrated that the porosity and swelling properties of GO/CS scaffolds can be altered by altering the ratio of GO to CS. More particularly, the swelling ratio of GO/CS scaffolds falls within the range of 23.20 to 27.38. As the concentration of GO increases from 0 to 0.1, 0.2, and 0.3%, the mechanical and physical characteristics have been significantly enhanced. The nanocomposite scaffolds facilitated the rapid growth of human articular chondrocytes (HAC) and contributed to an increase in the percentage of GO. This was particularly evident following 14 days of cultivation. For a 21-day in vitro culture period, a study on the morphology of HAC demonstrated a more spherical cell on the scaffolds.</p>

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Synthesis of Graphene Oxide/Chitosan Scaffolds for Bone Regeneration and Fracture Treatment

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Zhilin Yang

摘要

Abstract

Cartilage tissue engineering holds significant potential for regenerative medicine. In this study, we developed porous scaffolds composed of chitosan and graphene oxide (GO/CS) to enhance the properties and performance of scaffolds used for cartilage tissue regeneration. Findings of this study demonstrated that the porosity and swelling properties of GO/CS scaffolds can be altered by altering the ratio of GO to CS. More particularly, the swelling ratio of GO/CS scaffolds falls within the range of 23.20 to 27.38. As the concentration of GO increases from 0 to 0.1, 0.2, and 0.3%, the mechanical and physical characteristics have been significantly enhanced. The nanocomposite scaffolds facilitated the rapid growth of human articular chondrocytes (HAC) and contributed to an increase in the percentage of GO. This was particularly evident following 14 days of cultivation. For a 21-day in vitro culture period, a study on the morphology of HAC demonstrated a more spherical cell on the scaffolds.