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Abstract <p>Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, and Cd) in patients with two pathologies, lymphoma and leukemia, is considered.</p>

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Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • V. A. Trunova,
  • T. I. Pospelova,
  • M. S. Voytko,
  • E. S. Krupovich,
  • G. S. Soldatova,
  • R. O. Kuzmin,
  • K. S. Tsigulev

摘要

Abstract

Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, and Cd) in patients with two pathologies, lymphoma and leukemia, is considered.