Abstract <p>This study examines hydrogen desorption from hydrogenated titanium following irradiation with thermal neutrons. We use thermal desorption and thermopower methods in this work. Nuclear transformations occurring in neutron-irradiated titanium generate hydrogen, radioactive vanadium ⁵¹V, the gamma-emitting isotope ⁴⁶Sc, and γ quanta with energies ranging from 220 to 1120 keV depending on the neutron energy. The intensity of the γ radiation correlates with the hydrogen concentration in titanium preliminarily saturated with hydrogen. The presence of γ radiation must be considered when designing neutron shielding based on titanium. The irradiation of intermetallic compounds intended for hydrogen storage and transport results in titanium atom loss and disrupts the material’s initial stoichiometric composition as hydrogen exits the irradiation zone. The neutron irradiation of titanium alters the hydrogen concentration in the samples and redistributes hydrogen between the solid solution and titanium hydride phases.</p>