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Abstract <p>A poly <i>L</i>-arginine/β-cyclodextrin molecularly imprinted polymer-modified graphite electrode (PL-Arg/β-CD MIPs/GE) was developed for sensitive acetaminophen detection. The sensor achieved a wide linear range of 0.1–200 μmol L<sup>–1</sup> and a low detection limit of 0.022 μmol L<sup>–1</sup>, attributed to synergistic enrichment and electron transfer. It demonstrated excellent selectivity, reproducibility, and high recovery (98.20–102.80%) in real-sample analysis, showing great promise for practical drug monitoring applications.</p>

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A Poly L-Arginine/β-Cyclodextrin Molecularly Imprinted Nanocomposite for Highly Sensitive Electrochemical Detection of Acetaminophen

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Hong Sun,
  • Chuan Yao,
  • Wenxiao Zhang,
  • Jiayi Dang,
  • Chenguang Zhao,
  • Shicheng Wang,
  • Junyan Wang,
  • Jiwei Nie,
  • Shengju Wang

摘要

Abstract

A poly L-arginine/β-cyclodextrin molecularly imprinted polymer-modified graphite electrode (PL-Arg/β-CD MIPs/GE) was developed for sensitive acetaminophen detection. The sensor achieved a wide linear range of 0.1–200 μmol L–1 and a low detection limit of 0.022 μmol L–1, attributed to synergistic enrichment and electron transfer. It demonstrated excellent selectivity, reproducibility, and high recovery (98.20–102.80%) in real-sample analysis, showing great promise for practical drug monitoring applications.