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Abstract <p>The <i>XIAP</i> gene (also known as <i>BIRC4</i>) encodes the XIAP protein, which belongs to the inhibitor of apoptosis (IAP) family of proteins and demonstrates potent anti-apoptotic properties. XIAP is also involved in different intracellular signaling pathways, including the NF-κB pathway, the c-Jun N-terminal kinase pathway, and the TGF-β pathway. Disturbances in the expression and function of XIAP are primarily linked to the development of X-linked lymphoproliferative syndrome type 2, Crohn’s disease, neurodegenerative disorders, and the cancer pathogenesis. The role of XIAP in pathological processes remains an area of intensive research. This review summarizes current understanding of XIAP-mediated pathological processes and presents data on the potential for targeted therapy.</p>

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The Role of the XIAP Gene in Human Pathology

  • 期刊论文

  • 发表日期：

    2026年7月20日

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  • V. E. Shavrak,
  • N. A. Skryabin

摘要

Abstract

The XIAP gene (also known as BIRC4) encodes the XIAP protein, which belongs to the inhibitor of apoptosis (IAP) family of proteins and demonstrates potent anti-apoptotic properties. XIAP is also involved in different intracellular signaling pathways, including the NF-κB pathway, the c-Jun N-terminal kinase pathway, and the TGF-β pathway. Disturbances in the expression and function of XIAP are primarily linked to the development of X-linked lymphoproliferative syndrome type 2, Crohn’s disease, neurodegenerative disorders, and the cancer pathogenesis. The role of XIAP in pathological processes remains an area of intensive research. This review summarizes current understanding of XIAP-mediated pathological processes and presents data on the potential for targeted therapy.