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Abstract <p>This study examined genetic markers of organic pollutants (PCBs and DDE) in indigenous Siberian populations on the basis of an analysis of 59 genetic loci sensitive to organic pollutants. This list is based on published data regarding the presence of PCBs and DDE in the blood of Canadian Eskimos with different genotypes. The loci with the highest <i>PBS</i> statistics values, indicating a probable selective effect, were found in the <i>MTHFR</i> (rs2274976 and rs1801131), <i>GPX4</i> (rs713041), <i>TXNRD2</i> (rs5748469), and <i>ABCB1</i> (rs1128503) genes. Loci rs1133238 (<i>SEPHS2</i> gene) and rs732774 (<i>ATP7B</i> gene) are informative for PCBs, and locus rs2282143 (<i>SLC22A1</i> gene) is informative for DDE. In the indigenous populations of Siberia, it has been found that the increase in the frequency of alleles associated with elevated levels of organic pollutants in the blood occurs from south to northeast of Siberia. This may be due to the dietary characteristics of the indigenous peoples of the coastal areas of Northeastern Siberia and their traditional Arctic diet, which includes relatively high levels of pollutants, such as heavy metals and organochlorine compounds. Additionally, it has been demonstrated that a shared set of genes and metabolic pathways are associated with the detoxification of organic pollutants and heavy metals in the indigenous populations of the Far North of Asia.</p>

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Genetic Markers of Increased Vulnerability to Organic Pollutants in the Traditional Arctic Diet of the Indigenous Population of Siberia

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • N. V. Pokhilyuk,
  • B. A. Malyarchuk

摘要

Abstract

This study examined genetic markers of organic pollutants (PCBs and DDE) in indigenous Siberian populations on the basis of an analysis of 59 genetic loci sensitive to organic pollutants. This list is based on published data regarding the presence of PCBs and DDE in the blood of Canadian Eskimos with different genotypes. The loci with the highest PBS statistics values, indicating a probable selective effect, were found in the MTHFR (rs2274976 and rs1801131), GPX4 (rs713041), TXNRD2 (rs5748469), and ABCB1 (rs1128503) genes. Loci rs1133238 (SEPHS2 gene) and rs732774 (ATP7B gene) are informative for PCBs, and locus rs2282143 (SLC22A1 gene) is informative for DDE. In the indigenous populations of Siberia, it has been found that the increase in the frequency of alleles associated with elevated levels of organic pollutants in the blood occurs from south to northeast of Siberia. This may be due to the dietary characteristics of the indigenous peoples of the coastal areas of Northeastern Siberia and their traditional Arctic diet, which includes relatively high levels of pollutants, such as heavy metals and organochlorine compounds. Additionally, it has been demonstrated that a shared set of genes and metabolic pathways are associated with the detoxification of organic pollutants and heavy metals in the indigenous populations of the Far North of Asia.