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Abstract <p>COVID-19 is a severe acute respiratory infection caused by the SARS-CoV-2 virus. Research in the field of host genetics contributes to the discovery of new genomic markers of coronavirus infection progression. In this article, a method for multiplex genotyping of polymorphic variants of genes associated with the severity of COVID-19 has been developed, based on multilocus PCR and MALDI-TOF mass spectrometry of DNA molecules. The frequencies of 45 single nucleotide polymorphisms of COVID-19 candidate genes in a population sample of Russians from Tomsk are characterized. The results are compared with data for populations from the 1000 Genomes Project.</p>

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Development of the Multiplex Genotyping Method of Single-Nucleotide Polymorphisms of Genes Associated with the Severity of COVID-19

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • A. V. Bocharova,
  • E. A. Trifonova,
  • R. A. Korneeva,
  • A. A. Gusarova,
  • V. A. Stepanov

摘要

Abstract

COVID-19 is a severe acute respiratory infection caused by the SARS-CoV-2 virus. Research in the field of host genetics contributes to the discovery of new genomic markers of coronavirus infection progression. In this article, a method for multiplex genotyping of polymorphic variants of genes associated with the severity of COVID-19 has been developed, based on multilocus PCR and MALDI-TOF mass spectrometry of DNA molecules. The frequencies of 45 single nucleotide polymorphisms of COVID-19 candidate genes in a population sample of Russians from Tomsk are characterized. The results are compared with data for populations from the 1000 Genomes Project.