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Abstract <p>The article addresses the study of polymorphic variants of the rs2280090 <i>ADAM33</i> and rs1042714 <i>ADRB2</i> genes associated with a predisposition to bronchial asthma in the population of Eastern Siberia (Russian), Khakassia (Khakas), and Tuva (Tuvans). It was found that the <i>AG</i> genotype and the <i>A</i> allele of rs2280090 <i>ADAM33</i> are more common among Russians compared with Tuvans. Also it was detected that the <i>G</i> allele of rs1042717 <i>ADRB2</i> is significantly more common in Russians relative to Khakas, while the prevalence of the <i>GG</i> genotype is higher in Tuvans compared to Khakas. The findings highlight the importance of ethnic differences in predisposition to bronchial asthma and may be useful for developing strategies for the prevention and treatment of this disease.</p>

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Prevalence of Allele Variants of ADAM33 (rs2280090) and ADRB2 (rs1042714) in Siberian Populations

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • K. V. Afonicheva,
  • S. Yu. Tereshchenko,
  • M. V. Smolnikova

摘要

Abstract

The article addresses the study of polymorphic variants of the rs2280090 ADAM33 and rs1042714 ADRB2 genes associated with a predisposition to bronchial asthma in the population of Eastern Siberia (Russian), Khakassia (Khakas), and Tuva (Tuvans). It was found that the AG genotype and the A allele of rs2280090 ADAM33 are more common among Russians compared with Tuvans. Also it was detected that the G allele of rs1042717 ADRB2 is significantly more common in Russians relative to Khakas, while the prevalence of the GG genotype is higher in Tuvans compared to Khakas. The findings highlight the importance of ethnic differences in predisposition to bronchial asthma and may be useful for developing strategies for the prevention and treatment of this disease.