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Abstract <p>The article presents an analysis of the secondary, tertiary structures and conformation changes in 3D protein models as a result of spontaneous mutations in genes associated with maize (<i>Zea mays</i> L.) gynogenesis and embryogenesis. In particular, it was found that the four-nucleotides insertion into the <i>Zm_Mtl/Nld/Pla1</i> gene sequence leads to substitution of two α-helices with an unstructured section and a change in the amino acid composition of one of the β-folds in haploid-inducing (Stock 6, ZMS-8, ZMS-P) maize lines. The SNP at 131 position from the <i>Zm_Dmp7</i>/<i>Duf679</i> gene starting codon change the α-helix position in the haploid-inducing line CAU5 change, unlike the ZMS-8 line, which has a similar SNP and two additional amino acid substitutions. On the other hand, the SNP in the <i>Zm_Bbm1</i> gene from parthenogenetic line AT-4 and <i>Zm_CenH3</i> gene of haploid-inducing (ZMS-8, ZMS-P), and control (KM) maize lines do not lead to the amino acid substitutions in the corresponding proteins.</p>

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Conformation of 3D Protein Models after Mutations in Genes Associated with Maize Haploid Induction and Embryogenesis

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • V. V. Fadeev,
  • Yu. V. Fadeeva,
  • Ye. M. Moiseeva,
  • M. I. Chumakov

摘要

Abstract

The article presents an analysis of the secondary, tertiary structures and conformation changes in 3D protein models as a result of spontaneous mutations in genes associated with maize (Zea mays L.) gynogenesis and embryogenesis. In particular, it was found that the four-nucleotides insertion into the Zm_Mtl/Nld/Pla1 gene sequence leads to substitution of two α-helices with an unstructured section and a change in the amino acid composition of one of the β-folds in haploid-inducing (Stock 6, ZMS-8, ZMS-P) maize lines. The SNP at 131 position from the Zm_Dmp7/Duf679 gene starting codon change the α-helix position in the haploid-inducing line CAU5 change, unlike the ZMS-8 line, which has a similar SNP and two additional amino acid substitutions. On the other hand, the SNP in the Zm_Bbm1 gene from parthenogenetic line AT-4 and Zm_CenH3 gene of haploid-inducing (ZMS-8, ZMS-P), and control (KM) maize lines do not lead to the amino acid substitutions in the corresponding proteins.