Searching for Ethnospecific Risk Markers of Paranoid Schizophrenia in Bashkirs Based on the Results from Genome-Wide Association Study

It is now known that schizophrenia is a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes that increase susceptibility to schizophrenia have been identified. The objective of this study was to examine genetic factors associated with the risk of developing schizophrenia by conducting a genome-wide association study (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Genome-wide genotyping of DNA samples was carried using a PsychChip biochip, which included 610000 single nucleotide polymorphisms (SNPs).