Abstract <p>Tomato (<i>Solanum lycopersicum</i> L.) production is increasingly constrained by major abiotic stresses such as drought, salinity and high temperature, which often occur simultaneously under field conditions and adversely affect growth, physiological performance, fruit quality and yield. These stresses disrupt plant water relations, nutrient homeostasis, photosynthetic efficiency, hormonal balance and cellular redox stability, thereby posing a challenge to sustainable tomato production under changing climatic conditions. Evidence from recent studies suggests that single-factor interventions may be insufficient to ensure consistent stress tolerance. In this context, the “triple alliance” concept, integrating balanced mineral nutrition, plant growth regulators (PGRs) or biostimulants and beneficial microbial consortia, has been proposed as a potential integrative framework for stress mitigation. Microbial consortia may enhance root development, nutrient and water uptake and systemic tolerance; PGRs and biostimulants may regulate hormonal signaling and antioxidant defense systems; and nutrients provide essential metabolic and structural support for stress adaptation. This review synthesizes current knowledge on the physiological, biochemical and molecular responses of tomato to drought, salinity and heat stress and discusses the potential cooperative roles of the triple alliance components. In addition, this framework may contribute to improved plant defense responses, supporting integrated pest management strategies. However, the combined effects of all three components have not been extensively validated under uniform experimental or field conditions. Therefore, the triple alliance should be considered a conceptual and hypothesis-driven framework that requires further experimental validation. Overall, this approach may offer a promising and sustainable strategy to enhance tomato resilience, stabilize yield and maintain fruit quality under stress conditions, subject to further validation</p>