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Abstract <p>Ibuprofen (IBU) is among the world’s most popular and widely used nonsteroidal anti-inflammatory drugs (NSAIDs). Despite the prevalence of the pharmaceutical drugs in water and sediments worldwide, the effects of IBU on plants are largely unknown. In this work, the effect of IBU on wheat plants <i>Triticum aestivum</i> L. cv. Ekada 70 under normal and salinization (100 mM NaCl) was analyzed. Seed priming with 100&#xa0;μM IBU has a growth-promoting and protective effect on the growth parameters (germination energy, length, biomasses) of 5-day-old wheat plants. IBU causes accumulation of chlorophylls <i>a</i> and <i>b</i> as well as carotenoids, which increases photosynthesis. Under salinity, treatment prevents stress-induced depletion of photosynthetic pigments. The ability of drug to increase antioxidant potential of plants was found, which is reflected in the balanced generation of ROS (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\({\text{O}}_{2}^{{\bullet - }}\)</EquationSource> <!--PlntPhys2560048Maslennikova-m1--> </InlineEquation> and H<sub>2</sub>O<sub>2</sub>) and activation of SOD and CAT. Under stress, IBU treatment reduced the damaging accumulation of ROS and excessive activation of enzymes, exerting a protective effect on the antioxidant system, which is confirmed by data on lipid peroxidation. For the first time, it was discovered that the growth-stimulating effect of the drug is associated with its ability to influence the content of NO. The application of cPTIO revealed the existence of NO-independent pathways to regulate growth and sustainability in IBU implemented effects.</p>

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Ibuprofen Regulates Redox Metabolism and Nitric Oxide Content in Early Growth Stages of Wheat Plants

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • D. R. Maslennikova

摘要

Abstract

Ibuprofen (IBU) is among the world’s most popular and widely used nonsteroidal anti-inflammatory drugs (NSAIDs). Despite the prevalence of the pharmaceutical drugs in water and sediments worldwide, the effects of IBU on plants are largely unknown. In this work, the effect of IBU on wheat plants Triticum aestivum L. cv. Ekada 70 under normal and salinization (100 mM NaCl) was analyzed. Seed priming with 100 μM IBU has a growth-promoting and protective effect on the growth parameters (germination energy, length, biomasses) of 5-day-old wheat plants. IBU causes accumulation of chlorophylls a and b as well as carotenoids, which increases photosynthesis. Under salinity, treatment prevents stress-induced depletion of photosynthetic pigments. The ability of drug to increase antioxidant potential of plants was found, which is reflected in the balanced generation of ROS ( \({\text{O}}_{2}^{{\bullet - }}\) and H2O2) and activation of SOD and CAT. Under stress, IBU treatment reduced the damaging accumulation of ROS and excessive activation of enzymes, exerting a protective effect on the antioxidant system, which is confirmed by data on lipid peroxidation. For the first time, it was discovered that the growth-stimulating effect of the drug is associated with its ability to influence the content of NO. The application of cPTIO revealed the existence of NO-independent pathways to regulate growth and sustainability in IBU implemented effects.