Effect of Composition of Nonionic and Cationic Copolymers of Alkoxyoligo(ethylene glycol) Methacrylates and Dodecyl Methacrylate on Their Properties in Solutions

The properties of nonionic and cationic molecular brushes, the copolymers of methoxy- or higher n-alkoxyoligo(ethylene glycol) methacrylates with dodecyl methacrylate and terpolymers additionally containing cationic units of N-methacryloylaminopropyl-N,N-dimethyl-N-propylammonium bromide, in water, organic solvents, and two-phase systems water–hydrocarbon and aqueous saline solution–hydrocarbon have been studied. Effect of the composition of molecular brushes, calculated values of their hydrophilic–hydrophobic balance, solvent polarity, and temperature on the solubility of the polymers, micellization (critical micelle concentration and sizes of macromolecular associates), phase transition conditions, and interfacial activity is estimated. A set of properties of the presented molecular brushes allows their inclusion in a number of potential polymeric micellar nanocontainers for controlled drug delivery into the body.