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Abstract <p>A sample of 17 patients with resistant arterial hypertension combined with obstructive coronary atherosclerosis who had indications for coronary bypass surgery was examined. As part of a laboratory and instrumental examination, the patients underwent 24-h blood pressure monitoring in a hospital setting. The reaction of isolated myocardial trabeculae isolated from intraoperative biopsies taken during coronary bypass surgery to the action of β-adrenergic receptor agonists (β-AR) was studied. The association of 24-h blood pressure monitoring with the force of the overall inotropic response of myocardial trabeculae to β-AR stimulation was assessed. It was shown that isolated myocardial trabeculae of patients with average daily systolic&#xa0;blood pressure &lt;130 mmHg had a statistically more pronounced (<i>p</i> = 0.03) overall inotropic response to β-AR stimulation than those of patients with average daily systolic blood pressure &gt;130 mmHg. The force of the overall inotropic response of the trabeculae to β-AR stimulation has an inverse correlation with systolic and diastolic pressure. Significant correlations (<i>p</i> &lt; 0.05) were found in the average daily, average night-time, and average day-time formats of blood pressure assessment. It is suggested that the observed lack of differences between the daytime and nighttime periods is due to a more pronounced state of hyperexcitation of the autonomic nervous system in patients with resistant hypertension combined with obstructive coronary atherosclerosis.</p>

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Correlation of 24-Hour Monitoring of Arterial Pressure with the Inotropic Response of Isolated Myocardial Trabeculas to β-Adrenergic Stimulation in Resistant Arterial Hypertension Combined with Obstructive Coronary Atherosclerosis

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • S. A. Afanasiev,
  • D. S. Kondratieva,
  • E. F. Muslimova,
  • V. A. Korepanov,
  • S. L. Andreev,
  • V. A. Lichikaki,
  • M. A. Manukyan,
  • I. V. Zyubanova,
  • E. I. Solonskaya,
  • S. A. Khunkhinova,
  • V. F. Mordovin,
  • A. Yu. Falkovskaya

摘要

Abstract

A sample of 17 patients with resistant arterial hypertension combined with obstructive coronary atherosclerosis who had indications for coronary bypass surgery was examined. As part of a laboratory and instrumental examination, the patients underwent 24-h blood pressure monitoring in a hospital setting. The reaction of isolated myocardial trabeculae isolated from intraoperative biopsies taken during coronary bypass surgery to the action of β-adrenergic receptor agonists (β-AR) was studied. The association of 24-h blood pressure monitoring with the force of the overall inotropic response of myocardial trabeculae to β-AR stimulation was assessed. It was shown that isolated myocardial trabeculae of patients with average daily systolic blood pressure <130 mmHg had a statistically more pronounced (p = 0.03) overall inotropic response to β-AR stimulation than those of patients with average daily systolic blood pressure >130 mmHg. The force of the overall inotropic response of the trabeculae to β-AR stimulation has an inverse correlation with systolic and diastolic pressure. Significant correlations (p < 0.05) were found in the average daily, average night-time, and average day-time formats of blood pressure assessment. It is suggested that the observed lack of differences between the daytime and nighttime periods is due to a more pronounced state of hyperexcitation of the autonomic nervous system in patients with resistant hypertension combined with obstructive coronary atherosclerosis.