Abstract <p>The article examines various methods for processing uranium hexafluoride depleted in the ²³⁵U isotope, which is the main by-product of the isotopic enrichment of natural uranium in the production of nuclear fuel. These include reduction with hydrogen and other hydrogen-containing substances, energy-based processes, its use as a fluorinating agent in the production of organic and inorganic fluorine substances, and low-temperature and high-temperature hydrolysis, including the use of plasma torches. It is shown that the most preferred processing method is the hydrolysis of UF₆, achieved by the interaction of uranium hexafluoride with hydrogen-containing substances (methane, hydrogen) and oxygen in combustion mode. This method gives uranium oxides and hydrogen fluoride, which are convenient to store and can be used to close the nuclear fuel cycle with respect to fluorine. This method eliminates the need to maintain the surfaces of process equipment at high temperatures, since the thermal energy in the reaction zone is released during the interaction of the initial substances.</p>