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Abstract <p>Iodine-131 is frequently used in nuclear medicine for both diagnosis and treatment of thyroid conditions. Given that it’s radioactive and potentially linked to thyroid cancer, patients usually undergo monitoring for a week to avoid harm from the radioactive iodine. Graphene oxide’s electrical and mechanical traits have led to its widespread study in biomedicine. Its adsorption process utilizes its large surface area, porous structure, and functional groups that enable attractants to bind. This research employed the modified Hammer method to synthesize and characterize graphene oxide, utilizing it to remove iodine both in the laboratory and in living subjects. Results showed the produced graphene oxide structures were nanoscale, thus increasing the surface available for adsorption. The lab tests on adsorption showed they followed the Langmuir model, with optimal adsorption at 50 mg graphene oxide, pH 7.4, 37°C, and a 35-min contact time. Moreover, the results revealed graphene oxide did not negatively affect the rabbits’ liver or kidney functions, and the clearance rate observed in the living subjects was 71.95%.</p>

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Synthesis and Efficacy Study of Graphene Oxide for Removal of Radioactive Iodine I-131 In Vitro and In Vivo

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Aws Z. Abdulmajeed,
  • AlaUlddin M. Mahdi,
  • Lubna W. Mohammed,
  • Liqaa Hussain,
  • Luma D. Ibrahim,
  • Ali M. Salih

摘要

Abstract

Iodine-131 is frequently used in nuclear medicine for both diagnosis and treatment of thyroid conditions. Given that it’s radioactive and potentially linked to thyroid cancer, patients usually undergo monitoring for a week to avoid harm from the radioactive iodine. Graphene oxide’s electrical and mechanical traits have led to its widespread study in biomedicine. Its adsorption process utilizes its large surface area, porous structure, and functional groups that enable attractants to bind. This research employed the modified Hammer method to synthesize and characterize graphene oxide, utilizing it to remove iodine both in the laboratory and in living subjects. Results showed the produced graphene oxide structures were nanoscale, thus increasing the surface available for adsorption. The lab tests on adsorption showed they followed the Langmuir model, with optimal adsorption at 50 mg graphene oxide, pH 7.4, 37°C, and a 35-min contact time. Moreover, the results revealed graphene oxide did not negatively affect the rabbits’ liver or kidney functions, and the clearance rate observed in the living subjects was 71.95%.