Quantitative Assessment of the Hydrate Shell Thickness of Lactose Monohydrate Molecules in Aqueous Solutions
摘要
Abstract
The effect of solvents similar in physical properties to water on the formation of a hydrate shell around lactose monohydrate molecules has been studied by terahertz spectroscopy in transmission mode. A relationship has been established between the concentration of aqueous solutions of lactose monohydrate and the thickness of its hydrate shell when dissolved in purified water, an aqueous solution of high dilution (HD) and an aqueous solution of high dilution with antibodies to interferon-gamma (HD Ab to IFNg). It was found that the solvent HD Ab to IFNg dissolves more lactose monohydrate molecules at the same volume compared to other studied solvents.