Scholarlink

Abstract <p>Two trialkyltin carboxylates (<b>C1</b>, <b>C2</b>) have been synthesized by the reaction of 3-(1,3-dioxo-1<i>H</i>-benzo[de]isoquinolin-2(3<i>H</i>)-yl)propanoic acid ligand (<b>HL</b>) with tributyltin oxide or bis[tris(2-methyl-2-phenylpropyl)tin oxide, respectively. The structures were characterized by elemental analysis, IR, <sup>1</sup>H, <sup>13</sup>C NMR spectroscopies, and X-ray crystal diffraction. Crystal structure analysis reveals that complex <b>C1</b> adopts a five-coordinated trigonal bipyramidal configuration, while complex <b>C2</b> features a four-coordinated tetrahedral geometry. These two complexes further expand into supramolecular structures through intermolecular interactions. The thermogravimetric analysis indicates that complexes <b>C1</b> and <b>C2</b> possess good thermal stability below 200 and 300°C, respectively. In vitro cancer cell growth inhibitory activity reveals that tributyltin complex <b>C1</b> demonstrates superior potency across all tested cancer cell lines.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis, Characterization, and In Vitro Cancer Cell Inhibitory Activity of Two Trialkyltin Carboxylates

  • 期刊论文

  • 发表日期：

    2026年7月29日

查看全文
  • Zhengqing Tang,
  • Xin Yan,
  • Lei Wu,
  • Wujiu Jiang,
  • Yuxing Tan

摘要

Abstract

Two trialkyltin carboxylates (C1, C2) have been synthesized by the reaction of 3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid ligand (HL) with tributyltin oxide or bis[tris(2-methyl-2-phenylpropyl)tin oxide, respectively. The structures were characterized by elemental analysis, IR, 1H, 13C NMR spectroscopies, and X-ray crystal diffraction. Crystal structure analysis reveals that complex C1 adopts a five-coordinated trigonal bipyramidal configuration, while complex C2 features a four-coordinated tetrahedral geometry. These two complexes further expand into supramolecular structures through intermolecular interactions. The thermogravimetric analysis indicates that complexes C1 and C2 possess good thermal stability below 200 and 300°C, respectively. In vitro cancer cell growth inhibitory activity reveals that tributyltin complex C1 demonstrates superior potency across all tested cancer cell lines.