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Abstract <p>The process of basic hydrolysis of ester protecting groups in amidine-type conjugates based on amino acids and the <i>closo</i>-dodecaborate anion has been studied. The influence of the structure of the esters used and the molar ratio of base: substrate on the reaction course was investigated. The selectivity and kinetics of the process were studied by reversed-phase high-performance liquid chromatography (RP-HPLC). The structure of the synthesized compounds was confirmed by multinuclear NMR spectroscopy and ESI mass spectrometry.</p>

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Basic Hydrolysis of Glycine Ester Derivatives Based on the closo-Dodecaborate Anion: From Thermodynamic to Kinetic Control

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • A. Sychyov,
  • M. N. Ryabchikova,
  • A. V. Nelyubin,
  • I. N. Klyukin,
  • A. P. Zhdanov,
  • K. Yu. Zhizhin,
  • N. T. Kuznetsov

摘要

Abstract

The process of basic hydrolysis of ester protecting groups in amidine-type conjugates based on amino acids and the closo-dodecaborate anion has been studied. The influence of the structure of the esters used and the molar ratio of base: substrate on the reaction course was investigated. The selectivity and kinetics of the process were studied by reversed-phase high-performance liquid chromatography (RP-HPLC). The structure of the synthesized compounds was confirmed by multinuclear NMR spectroscopy and ESI mass spectrometry.