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Abstract <p>An efficient method for the synthesis of conjugates of amino acids and nitrilium derivatives of boron clusters [B<sub><i>n</i></sub>H<sub><i>n</i></sub>]<sup>2–</sup> (<i>n</i> = 10, 12) has been developed. The proposed method allows for the preparation of target compounds in quantitative yields without complex purification procedures. The conditions for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) involving propargylglycine conjugates were optimized, including the selection of solvent and product isolation protocol. The structure of the synthesized compounds was established by multinuclear NMR spectroscopy and ESI mass spectrometry.</p>

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Amidine Derivatives of Boron Cluster Anions Based on Propargylglycine and Their Reactivity in Copper-Catalyzed Azide-Alkyne Cycloaddition Conditions

  • 期刊论文

  • 发表日期：

    2025年12月12日

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  • M. N. Ryabchikova,
  • A. V. Nelyubin,
  • I. N. Klyukin,
  • N. A. Selivanov,
  • A. Yu. Bykov,
  • A. P. Zhdanov,
  • K. Yu. Zhizhin,
  • N. T. Kuznetsov

摘要

Abstract

An efficient method for the synthesis of conjugates of amino acids and nitrilium derivatives of boron clusters [BnHn]2– (n = 10, 12) has been developed. The proposed method allows for the preparation of target compounds in quantitative yields without complex purification procedures. The conditions for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) involving propargylglycine conjugates were optimized, including the selection of solvent and product isolation protocol. The structure of the synthesized compounds was established by multinuclear NMR spectroscopy and ESI mass spectrometry.