Synthesis of Borylated Amidines Based on Closo-Dodecaborate Anion and Sulfur-Containing Amino Acids

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发表日期：

2024年12月1日

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M. N. Ryabchikova,
N. K. Neumolotov,
A. V. Nelyubin,
N. A. Selivanov,
A. Yu. Bykov,
A. P. Zhdanov,
K. Yu. Zhizhin,
N. T. Kuznetsov

摘要

Abstract

IA new method for synthesizing boronated amidines based on amino acids of the type [B₁₂H₁₁NHC(NHCHR'COOH)R]^– has been developed, which significantly increases the yield of target compounds. The process of obtaining conjugates of the closo-dodecaborate anion and sulfur-containing amino acids was studied. These derivatives show high potential for the development of new agents for BNCT (boron neutron capture therapy) based on boron-coated gold nanoparticles containing vector groups conjugated through peptide synthesis methods.