Functional Design of Peroral Iron Compound Delivery Systems Based on Polymethylsilsesquioxane Hydrogels for the Therapy of Iron Deficiency Anemia

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发表日期：

2024年4月1日

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P. D. Orlova,
I. B. Meshkov,
E. V. Latipov,
S. G. Vasil’ev,
A. A. Kalinina,
A. M. Muzafarov,
I. M. Le-Deygen

摘要

Abstract

An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variable structure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorption capacity toward a saturated solution of FeCl₃∙6H₂O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systems are studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.