Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

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发表日期：

2024年3月28日

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T. M. Garaev,
I. I. Yudin,
N. V. Breslav,
T. E. Savochkina,
A. S. Krepkaya,
T. V. Grebennikova,
S. E. Nikiforova,
I. I. Myshletsov,
V. V. Avdeeva,
E. A. Malinina

摘要

Abstract

This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral small-molecule agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used as zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of the influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.