Binding Studies of Novel Manganese Complexes to DNA

期刊论文
发表日期：

2024年2月1日

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B. Wang,
X. Y. Ma,
W. Yao,
S. Y. Wu,
Y. Zhang,
W. Liu,
E. J. Gao

摘要

Abstract

A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.