Hypercoordinate Germanium Complexes with Ligands Containing Hydroxyalkyl Groups

Among germatranes, 1-germatranol hydrate is the most well-studied compound with a broad spectrum of biological activity. It is synthesized in one step by the reaction of tris(2-hydroxyethyl)amine with germanium dioxide in an aqueous medium without the use of organic solvents. Using this approach, new potentially biologically active compounds of germanium with hydroxyalkylamines and sulfonic and amino acids containing hydroxyalkyl groups were synthesized. The products were considered as new analogues of biologically active 1-germatranol hydrate. Their formation was confirmed by the results of elemental analysis, IR and NMR spectroscopy. In silico ADME and Pass analysis were used to assess the potential bioavailability and pharmacological activity profiles for new compounds. The results of in vitro study of the antiviral activity (influenza virus A/Aichi/2/68 (H3N2)) of the synthesized compounds are presented.