Abstract <p>Data on the diversity and occurrence of anomalies in the development of the axial skeleton are presented for juveniles of six cyprinid fish species of Saratov Reservoir: roach (<i>Rutilus rutilus</i> Linnaeus, 1758), bleak (<i>Alburnus alburnus</i> Linnaeus, 1758), ide (<i>Leuciscus idus</i> Linnaeus, 1758), bream (<i>Abramis brama</i> Linnaeus, 1758), rudd (<i>Scardinius erythrophthalmus</i> Linnaeus, 1758), and white bream (<i>Blicca bjoerkna</i> Linnaeus, 1758). In total, 4 main types of axial skeletal abnormalities of varying severity and localization were diagnosed: scoliosis, lordosis, kyphosis, and underdevelopment of the caudal spine. The proportion of individuals with spinal disorders ranged from 0.5% in bream to 2.3% in bleak. The proportion of axial skeletal anomalies among other detected disorders ranged from 2.0% in bream to 9.9% in bleak, while the total proportion of abnormal individuals in the studied samples varied from 23.4 to 38.4%. There is a tendency of increasing the frequency of occurrence of axial skeleton anomalies in juvenile of the Saratov Reservoir with an increase of the anthropogenic load at different stations of the Reservoir.</p>