Studies of the Role of Phagocytes in Superficial Wound Healing in the Holothurian Eupentacta fraudatrix

The abundance and functional activity of two types of phagocytes of the sea cucumber Eupentacta fraudatrix have been studied at individual stages of wound healing. It is shown that the dynamics of the number of individual types of phagocytes and their viability do not correspond to those for coelomocytes. In this case, injury causes a shift in the proportion and opposite changes in the functional activity of different types of phagocytes, which also had opposite directions at the early and later stages of wound healing. The administration of proteins isolated from the coelomic fluid of regenerating holothurians to wounded individuals at different stages caused multidirectional shifts in the ratio of the two types of phagocytes and their activity compared to the effect of the wound itself. It has been concluded that the two types of phagocytes can play different roles in wound healing.