Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin

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发表日期：

2024年12月18日

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S. V. Revtovich,
V. V. Kulikova,
V. S. Koval,
A. D. Lyfenko,
V. A. Kazakov,
A. S. Chernov,
G. B. Telegin,
A. S. Zemskaya,
N. V. Anufrieva,
E. A. Morozova,
P. N. Solyev

摘要

Abstract

Acute and subchronic toxicity of the pharmacological pair based on encapsulated Citrobacter freundii C115H methionine γ-lyase enzyme/prodrug (methiin) was studied in female ICR mice. The drug showed a weak/moderate dose-dependent hepatotoxic effect. Most of the changes in liver morphology identified were insignificant or mild deviations from the norm. Long-term use of a single therapeutic dose per mouse of 1.5 U C. freundii C115H methionine γ-lyase @ (PEG−P(Asp)₇₀/PLL₇₀)-PIC-some/2 mg methiin led to a slight decrease in the weight of animals without obvious signs of intoxication. A quarter of the animals in this group had no deviations from the norm in liver morphology. No nephrotoxic effect was found in any study group.