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<b>Abstract</b>— <p>The copper-resistant bacterial strain <i>Achromobacter insolitus</i> LCu2 was selected as a model for studying bacterial resistance to heavy metals mediated by efflux proteins. Nine gene clusters of RND efflux systems, potentially responsible for heavy metal export from the cell and related to the previously described bacterial efflux systems, were identified in the strain LCu2 genome. Experimental studies demonstrated resistance of <i>A. insolitus</i> LCu2 to cadmium, zinc, chromium, and lead cations; its moderate tolerance to cobalt and nickel; and its sensitivity to silver cations. These results are important for further study of the genetic and metabolic mechanisms of bacterial resistance to heavy metals.</p>

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Diversity of the RND Efflux System Genes in the Genome of Achromobacter insolitus LCu2 Correlates with Its Heavy Metals Resistance

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • G. L. Burygin,
  • J. A. Balabanova,
  • A. S. Astankova,
  • Ye. V. Kryuchkova

摘要

Abstract—

The copper-resistant bacterial strain Achromobacter insolitus LCu2 was selected as a model for studying bacterial resistance to heavy metals mediated by efflux proteins. Nine gene clusters of RND efflux systems, potentially responsible for heavy metal export from the cell and related to the previously described bacterial efflux systems, were identified in the strain LCu2 genome. Experimental studies demonstrated resistance of A. insolitus LCu2 to cadmium, zinc, chromium, and lead cations; its moderate tolerance to cobalt and nickel; and its sensitivity to silver cations. These results are important for further study of the genetic and metabolic mechanisms of bacterial resistance to heavy metals.