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<b>Abstract</b>— <p>The purple non-sulfur bacterium <i>Cereibacter sphaeroides</i> VKM B-3534D is of both basic and applied significance as a producer of various valuable compounds. In this study, the complete genome of this bacterium was sequenced and assembled <i>de novo</i> for analysis of the pathways for the synthesis of tricarboxylic acids cycle intermediates via acetyl-CoA in comparison with related bacteria. Our analysis revealed that the metabolic capabilities for replenishing the pool of tricarboxylic acid cycle intermediates in the studied <i>C.&#xa0;sphaeroides</i> strains differed from those in <i>Rhodobacter capsulatus</i> B10. This was due to the absence of the glyoxylate shunt, the methylcitrate cycle and some of pathways for pyruvate formation from exogenous acetate and CO<sub>2</sub>, as well as the presence of the citramalate cycle and succinyl-CoA:acetate CoA-transferase genes.</p>

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Complete Genome Sequencing and Identification of Anaplerotic Pathways in Cereibacter sphaeroides VKM B-3534D

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • E. P. Petushkova,
  • P. A. Starygina,
  • E. V. Mayorova,
  • S. V. Toshchakov,
  • Z. B. Namsaraev,
  • A. A. Tsygankov

摘要

Abstract—

The purple non-sulfur bacterium Cereibacter sphaeroides VKM B-3534D is of both basic and applied significance as a producer of various valuable compounds. In this study, the complete genome of this bacterium was sequenced and assembled de novo for analysis of the pathways for the synthesis of tricarboxylic acids cycle intermediates via acetyl-CoA in comparison with related bacteria. Our analysis revealed that the metabolic capabilities for replenishing the pool of tricarboxylic acid cycle intermediates in the studied C. sphaeroides strains differed from those in Rhodobacter capsulatus B10. This was due to the absence of the glyoxylate shunt, the methylcitrate cycle and some of pathways for pyruvate formation from exogenous acetate and CO2, as well as the presence of the citramalate cycle and succinyl-CoA:acetate CoA-transferase genes.