Abstract <p>The potential danger of toxin-forming fungus <i>S. chartarum</i> in the walls of buildings in St. Petersburg was assessed, its chemotype-specific signs and toxicity of conidia and culture fluids were studied. For the first time in Russia, the composition of proteins, the relative quantitative content of trichothecene mycotoxins, and the qualitative composition of tryprenylphenols of this fungus were studied. It was noted that <i>S.&#xa0;chartarum</i> found in St. Petersburg buildings on cellulose-containing wet finishing materials, exceeding in abundance the other representatives of the mycobiota. It was shown that the toxic effect of conidia of <i>S. chartarum</i> strains against <i>Paramecium caudatum</i> was due to trichothecene mycotoxins, and the toxicity of culture liquids was due to tryprenylphenols, in particular stachybotrydial. Identified potential of 27% of the studied <i>S. chartarum</i> strains to synthesize macrocyclic trichothecene mycotoxins and of 53% of the strains to synthesize stachylysin indicate the danger of these micromycetes for residents of contaminated premises.</p>

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Physiological, Biochemical, and Toxigenic Properties of Stachybotrys chartarum Growing on Technogenic Substrates

  • E. V. Dorshakova,
  • A. A. Dalinova,
  • Y. A. Titova,
  • S. V. Sokornova,
  • V. R. Dubovik,
  • D. M. Kochura,
  • T. S. Bogomolova,
  • G. A. Chilina,
  • I. E. Pavlova,
  • N. V. Vasilyeva,
  • M. V. Rudneva,
  • A. O. Berestetskiy

摘要

Abstract

The potential danger of toxin-forming fungus S. chartarum in the walls of buildings in St. Petersburg was assessed, its chemotype-specific signs and toxicity of conidia and culture fluids were studied. For the first time in Russia, the composition of proteins, the relative quantitative content of trichothecene mycotoxins, and the qualitative composition of tryprenylphenols of this fungus were studied. It was noted that S. chartarum found in St. Petersburg buildings on cellulose-containing wet finishing materials, exceeding in abundance the other representatives of the mycobiota. It was shown that the toxic effect of conidia of S. chartarum strains against Paramecium caudatum was due to trichothecene mycotoxins, and the toxicity of culture liquids was due to tryprenylphenols, in particular stachybotrydial. Identified potential of 27% of the studied S. chartarum strains to synthesize macrocyclic trichothecene mycotoxins and of 53% of the strains to synthesize stachylysin indicate the danger of these micromycetes for residents of contaminated premises.