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Abstract <p>As a cell factory, yeast usually face various stresses caused by such environmental changes as temperature stress, osmotic stress, and toxic compounds stress. Stress can destroy the cell structure, interfere with metabolism, inhibit cell growth, and ultimately suppress the fermentation efficiency. To reduce the adverse effects of stress, yeast may regulate the metabolism of intracellular compatible osmolytes as one of the response strategies. Proline, one of the main compatible osmolytes, plays a positive role in various yeast stresses by maintaining osmotic balance, reducing nucleic acid cleavage temperature and protein aggregation, and removing excess reactive oxygen species. Finally, it increases the stability of cell structure and redox balance, and improves cell activity and fermentation efficiency. This review focused on the metabolic pathway of proline in yeasts, its key regulatory role in various stress responses, and the construction and application of proline-accumulating strains, thus providing ideas for the improvement of yeast stress tolerance and genetic modification of yeast strains.</p>

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Proline Metabolism and Its Regulatory Role in Yeast Stress Response

  • 期刊论文

  • 发表日期：

    2025年7月15日

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  • X. Z. Liu,
  • Y. J. Wang,
  • J. Gao,
  • Y. F. Li

摘要

Abstract

As a cell factory, yeast usually face various stresses caused by such environmental changes as temperature stress, osmotic stress, and toxic compounds stress. Stress can destroy the cell structure, interfere with metabolism, inhibit cell growth, and ultimately suppress the fermentation efficiency. To reduce the adverse effects of stress, yeast may regulate the metabolism of intracellular compatible osmolytes as one of the response strategies. Proline, one of the main compatible osmolytes, plays a positive role in various yeast stresses by maintaining osmotic balance, reducing nucleic acid cleavage temperature and protein aggregation, and removing excess reactive oxygen species. Finally, it increases the stability of cell structure and redox balance, and improves cell activity and fermentation efficiency. This review focused on the metabolic pathway of proline in yeasts, its key regulatory role in various stress responses, and the construction and application of proline-accumulating strains, thus providing ideas for the improvement of yeast stress tolerance and genetic modification of yeast strains.