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Abstract <p>We describe a user-friendly tool for identifying and classifying bacterial transcription factors (TFs). It uses hidden Markov models (HMMs) to detect DNA-binding domains and classify TFs from bacterial genomes. BacTFid outperforms existing tools by accurately identifying a wide range of TFs, including those with non-helix-turn-helix folds, while minimizing false positives. Available as a web service and a desktop application, BacTFid provides an easy-to-use interface for microbiologists, delivering comprehensive TF identification from user-provided genome files. This tool should facilitate research into bacterial transcriptional regulation and genome annotation.</p>

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BacTFid—A Simple, Efficient Bacterial Transcription Factor Identifier and Classifier

  • 期刊论文

  • 发表日期：

    2025年6月14日

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  • P. Vychyk,
  • A. Digris,
  • E. Duvalov,
  • V. Skakun,
  • Y. Nikolaichik

摘要

Abstract

We describe a user-friendly tool for identifying and classifying bacterial transcription factors (TFs). It uses hidden Markov models (HMMs) to detect DNA-binding domains and classify TFs from bacterial genomes. BacTFid outperforms existing tools by accurately identifying a wide range of TFs, including those with non-helix-turn-helix folds, while minimizing false positives. Available as a web service and a desktop application, BacTFid provides an easy-to-use interface for microbiologists, delivering comprehensive TF identification from user-provided genome files. This tool should facilitate research into bacterial transcriptional regulation and genome annotation.