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<b>Abstract</b>— <p>The increasing interest in the so-called rare genera of actinomycetes is due to the fact that their potential as producers of valuable metabolites, primarily antibiotic, has been studied insufficiently. The use of selective methods made it possible to isolate the YrIIa5 strain from the soil collected near the Dutch Fortress (Rostov, Yaroslavl oblast). Phylogenetic analysis based on the similarity of the 16S rRNA genes and five housekeeping genes (MLSA) allowed us to assign the isolate to the genus <i>Krasilnikoviella</i>. Genome analysis revealed many genes responsible for resistance to a wide range of antibiotics, which was confirmed by studying the strain for sensitivity to antimicrobial compounds using the agar diffusion method.</p>

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Genomic and Functional Analysis of a Multidrug Resistant Strain YRIIA5, a Member of the Rare Genus Krasilnikoviella

  • 期刊论文

  • 发表日期：

    2025年2月28日

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  • A. R. Kiriy,
  • Yu. V. Zakalyukina,
  • Yu. A. Buyuklyan,
  • M. V. Biryukov

摘要

Abstract—

The increasing interest in the so-called rare genera of actinomycetes is due to the fact that their potential as producers of valuable metabolites, primarily antibiotic, has been studied insufficiently. The use of selective methods made it possible to isolate the YrIIa5 strain from the soil collected near the Dutch Fortress (Rostov, Yaroslavl oblast). Phylogenetic analysis based on the similarity of the 16S rRNA genes and five housekeeping genes (MLSA) allowed us to assign the isolate to the genus Krasilnikoviella. Genome analysis revealed many genes responsible for resistance to a wide range of antibiotics, which was confirmed by studying the strain for sensitivity to antimicrobial compounds using the agar diffusion method.