Abstract <p>This paper presents a modern comprehensive approach to the analysis and design of reinforced concrete buildings, taking into account soil-structure interaction (SSI) under seismic loading. As a case study, the approach was applied to the seismic analysis of a five-story reinforced concrete building. The external seismic impact was defined using a three-component accelerogram corresponding to a magnitude-9 earthquake. The interaction between the building and the soil foundation was implemented through an SSI interface (soil-structure interaction). To eliminate the influence of wave reflections from the boundaries of the finite soil domain, a perfectly matched layer (PML) was employed. The reinforced concrete structures were modeled using a method that combines solid elements for concrete with beam elements for reinforcement. The simulations were performed using distributed computing technology on a high-performance computing cluster. A study of the failure mechanisms of the structure was carried out. A comparative analysis was conducted between the input accelerogram at the free surface of the soil and the acceleration recorded at the building’s foundation slab. With appropriate adaptation and the use of high-performance computing systems, the proposed methodology can be applied in engineering practice to improve the reliability of seismic analysis of reinforced concrete buildings.</p>