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Abstract <p>Complexes [AgL(NO<sub>3</sub>)] (<b>I</b>), [AgL<sup>1</sup>(NO<sub>3</sub>)] (<b>II</b>) and [Ag(μ-NO<sub>3</sub>)L<sup>2</sup>]<sub><i>n</i></sub> (<b>III)</b>, (L, L<sup>1</sup>, L<sup>2</sup> are nopinane-annelated 4-aza- and 4,5-diazafluorene derivatives) are prepared. The molecular structures of <b>I</b>, <b>II</b>, and that of the [Ag(μ-NO<sub>3</sub>)L<sup>2</sup>]<sub><i>n</i></sub>·0.5Et<sub>2</sub>O (<b>IV</b>) solvate are established by single crystal X-ray diffraction (CCDC No. 2546650, 2546708, 2546710). The crystal structures of <b>I</b> and <b>II</b> are built of supramolecular dimeric ensembles formed by molecules of two-coordinate and three-coordinate silver(I) complexes, respectively. The dimeric ensembles in <b>II</b> are additionally stabilized by argentophilic interactions (Ag⋯Ag 2.92&#xa0;Å). Compound <b>IV</b> contains a polynuclear complex <b>III</b> and diethyl ether molecules. Ligand L is monodentate, whereas L<sup>1</sup> and L<sup>2</sup> are bidentate cyclic ligands. The compounds are characterized by elemental analysis, X-ray powder diffraction, and NMR spectroscopy. The cytotoxic properties of the free ligands L<sup>1</sup>, L<sup>2</sup>, complexes <b>II</b> and <b>III</b>, and the previously obtained nopinane-annelated 4,5-diazafluorenone L<sup>3</sup> and <InlineEquation ID="IEq1"> <EquationSource Format="TEX">$[\text{Ag}{{(\text{L}_{\text{N}\text{,N}}^{ 3})}_{2}}]\text{N}{{\text{O}}_{3}}\cdot \text{EtOH}\cdot {{\text{H}}_{2}}\text{O}$</EquationSource> </InlineEquation> (<b>V</b>) are investigated against the breast adenocarcinoma cell line MCF-7 and the non‑tumor human lung fibroblast cell line MRC-5.</p>

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Silver(I) Complexes with Nopinane-Annelated 4-Aza- and 4,5-Diazafluorene Derivatives

  • 期刊论文

  • 发表日期：

    2026年7月30日

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  • T. E. Kokina,
  • E. S. Vasilyev,
  • L. A. Glinskaya,
  • Yu. A. Golubeva,
  • L. S. Klyushova,
  • A. M. Agafontsev,
  • T. S. Sukhikh,
  • A. V. Tkachev

摘要

Abstract

Complexes [AgL(NO3)] (I), [AgL1(NO3)] (II) and [Ag(μ-NO3)L2]n (III), (L, L1, L2 are nopinane-annelated 4-aza- and 4,5-diazafluorene derivatives) are prepared. The molecular structures of I, II, and that of the [Ag(μ-NO3)L2]n·0.5Et2O (IV) solvate are established by single crystal X-ray diffraction (CCDC No. 2546650, 2546708, 2546710). The crystal structures of I and II are built of supramolecular dimeric ensembles formed by molecules of two-coordinate and three-coordinate silver(I) complexes, respectively. The dimeric ensembles in II are additionally stabilized by argentophilic interactions (Ag⋯Ag 2.92 Å). Compound IV contains a polynuclear complex III and diethyl ether molecules. Ligand L is monodentate, whereas L1 and L2 are bidentate cyclic ligands. The compounds are characterized by elemental analysis, X-ray powder diffraction, and NMR spectroscopy. The cytotoxic properties of the free ligands L1, L2, complexes II and III, and the previously obtained nopinane-annelated 4,5-diazafluorenone L3 and $[\text{Ag}{{(\text{L}_{\text{N}\text{,N}}^{ 3})}_{2}}]\text{N}{{\text{O}}_{3}}\cdot \text{EtOH}\cdot {{\text{H}}_{2}}\text{O}$ (V) are investigated against the breast adenocarcinoma cell line MCF-7 and the non‑tumor human lung fibroblast cell line MRC-5.