Scholarlink

Abstract <p>New cobalt(II) and copper(I) complexes, [CoCl<sub>2</sub>(L<sup>1</sup>)<sub>2</sub>] (<b>1</b>) and [CuClL<sup>2</sup>(Ph<sub>3</sub>P)<sub>2</sub>]·CH<sub>3</sub>CN (<b>2</b>), where L<sup>1</sup>&#xa0;=&#xa0;1-(4-bromobenzylidene)thiosemicarbazide, L<sup>2</sup>&#xa0;=&#xa0;1-(2,4-dichlorobenzylidene)thiosemicarbazide, PPh<sub>3</sub>&#xa0;==&#xa0;triphenylphosphine, were synthesized and characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The complexes were also tested for their urease inhibitory properties. The cobalt complex has strong activity (<i>IC</i><sub>50</sub>&#xa0;=&#xa0;5.7&#xa0;μM). Enzymatic kinetics research suggested that the cobalt complex is a non-competitive urease inhibitor.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis, Structures and Urease Inhibition Studies of Cobalt(II) and Copper(I) Complexes with Thiosemicarbazone Ligands

  • 期刊论文

  • 发表日期：

    2026年1月1日

查看全文
  • Y. -X. Chen,
  • B. Qiu,
  • Y. -J. Xu,
  • W. -B. Yan,
  • S. -J. Liu,
  • X. -Y. Qiu

摘要

Abstract

New cobalt(II) and copper(I) complexes, [CoCl2(L1)2] (1) and [CuClL2(Ph3P)2]·CH3CN (2), where L1 = 1-(4-bromobenzylidene)thiosemicarbazide, L2 = 1-(2,4-dichlorobenzylidene)thiosemicarbazide, PPh3 == triphenylphosphine, were synthesized and characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The complexes were also tested for their urease inhibitory properties. The cobalt complex has strong activity (IC50 = 5.7 μM). Enzymatic kinetics research suggested that the cobalt complex is a non-competitive urease inhibitor.