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Abstract <p>The structure of <i>trans</i>,<i>trans</i>-[Pt(py)<sub>2</sub>(N<sub>3</sub>)<sub>2</sub>(OH)<sub>2</sub>]·2H<sub>2</sub>O is studied by single crystal X-ray diffraction. The crystallographic data are: <i>a</i>&#xa0;=&#xa0;9.8240(2)&#xa0;Å, <i>b</i>&#xa0;=&#xa0;17.2178(3)&#xa0;Å, <i>c</i>&#xa0;=&#xa0;9.5248(2)&#xa0;Å, β&#xa0;=&#xa0;97.777(1)°, space group <i>P</i>2<sub>1</sub>/<i>c</i>, <i>Z</i>&#xa0;=&#xa0;4, ρ<sub>cal</sub>&#xa0;=&#xa0;2.11&#xa0;g/cm<sup>3</sup>. The crystal structure of the complex consists of molecular layers perpendicular to the <i>c</i> direction. The transformation process of the dehydrate to the anhydrous complex is analyzed by thermal gravimetry. The previously published synthesis procedures of <i>trans</i>,<i>trans</i>-[Pt(py)<sub>2</sub>(N<sub>3</sub>)<sub>2</sub>(OH)(SuccH)] and <i>trans</i>,<i>trans</i>-[Pt(py)<sub>2</sub>(N<sub>3</sub>)<sub>2</sub>(OH)(Succ-NH-TEMPO)] complexes from <i>trans</i>,<i>trans</i>-[Pt(py)<sub>2</sub>(N<sub>3</sub>)<sub>2</sub>(OH)<sub>2</sub>] are modified. The optimization of synthesis conditions and the product isolation procedure increases the product yield and substantially improves the purity of the obtained compounds.</p>

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Structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O and Synthesis of Pt(IV) Prodrugs Based on It

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • A. E. Zazulya,
  • P. A. Abramov,
  • S. V. Tkachev,
  • D. G. Sheven’,
  • A. Yu. Komarovskikh,
  • P. E. Plyusnin,
  • D. B. Vasilchenko

摘要

Abstract

The structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O is studied by single crystal X-ray diffraction. The crystallographic data are: a = 9.8240(2) Å, b = 17.2178(3) Å, c = 9.5248(2) Å, β = 97.777(1)°, space group P21/c, Z = 4, ρcal = 2.11 g/cm3. The crystal structure of the complex consists of molecular layers perpendicular to the c direction. The transformation process of the dehydrate to the anhydrous complex is analyzed by thermal gravimetry. The previously published synthesis procedures of trans,trans-[Pt(py)2(N3)2(OH)(SuccH)] and trans,trans-[Pt(py)2(N3)2(OH)(Succ-NH-TEMPO)] complexes from trans,trans-[Pt(py)2(N3)2(OH)2] are modified. The optimization of synthesis conditions and the product isolation procedure increases the product yield and substantially improves the purity of the obtained compounds.