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Abstract <p>Complex compounds [CuL(phen)(H<sub>2</sub>O)(NO<sub>3</sub>)]NO<sub>3</sub> (<b>1</b>), [CuL(bipy)(NO<sub>3</sub>)<sub>2</sub>]·2EtOH (<b>2</b>), [CuL<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub> (NO<sub>3</sub>)<sub>2</sub>] (<b>2a</b>), [CuL(dmbipy)(NO<sub>3</sub>)<sub>2</sub>]·3EtOH (<b>3</b>), and [CuL<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>] (<b>3a</b>), where L is 3-(5-phenyl-2H-tetrazol-2-yl)pyridine, phen is 1,10-phenanthroline, bipy is 2,2′-bipyridine, and dmbipy is 4,4′-dimethyl-2,2′-bipyridine, are obtained and structurally characterized. It is shown that L behaves as the monodentate ligand being coordinated by the nitrogen atom of the pyridine ring. The coordination polyhedron made of copper atoms is a square pyramid in complexes <b>1</b> and <b>3, </b>a distorted octahedron and a distorted square in complexes <b>2a</b> and <b>3a </b>respectively. Complex <b>1</b> is characterized by the elemental analysis, powder X-ray diffraction, and IR spectroscopy. Furthermore, its cytotoxic properties are studied on human larynx carcinoma (Hep2), breast adenocarcinoma (MCF7), and non-tumor human fibroblast (MRC5) cell lines. Complex <b>1</b> is shown to exhibit the pronounced cytotoxic action (<i>LC</i><sub>50</sub>(Hep2)&#xa0;=&#xa0;4.1±0.4&#xa0;µM and <i>LC</i><sub>50</sub>(MCF7)&#xa0;=&#xa0;4.9±0.1&#xa0;µM), however, does not exhibit selectivity against tumor cell lines (<i>LC</i><sub>50</sub>(MRC5)&#xa0;= =&#xa0;3.06 ±0.02&#xa0;µM).</p>

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Structural Features of Copper(II) Complexes Based on 3-(5-phenyl-2H-tetrazol-2-yl)Pyridine and 2,2′-Bipyridine/1,10-Phenanthroline

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • E. A. Ermakova,
  • K. S. Smirnova,
  • L. S. Klyushova,
  • I. S. Chernov,
  • V. A. Ostrovskii,
  • E. V. Lider

摘要

Abstract

Complex compounds [CuL(phen)(H2O)(NO3)]NO3 (1), [CuL(bipy)(NO3)2]·2EtOH (2), [CuL2(H2O)2 (NO3)2] (2a), [CuL(dmbipy)(NO3)2]·3EtOH (3), and [CuL2(NO3)2] (3a), where L is 3-(5-phenyl-2H-tetrazol-2-yl)pyridine, phen is 1,10-phenanthroline, bipy is 2,2′-bipyridine, and dmbipy is 4,4′-dimethyl-2,2′-bipyridine, are obtained and structurally characterized. It is shown that L behaves as the monodentate ligand being coordinated by the nitrogen atom of the pyridine ring. The coordination polyhedron made of copper atoms is a square pyramid in complexes 1 and 3, a distorted octahedron and a distorted square in complexes 2a and 3a respectively. Complex 1 is characterized by the elemental analysis, powder X-ray diffraction, and IR spectroscopy. Furthermore, its cytotoxic properties are studied on human larynx carcinoma (Hep2), breast adenocarcinoma (MCF7), and non-tumor human fibroblast (MRC5) cell lines. Complex 1 is shown to exhibit the pronounced cytotoxic action (LC50(Hep2) = 4.1±0.4 µM and LC50(MCF7) = 4.9±0.1 µM), however, does not exhibit selectivity against tumor cell lines (LC50(MRC5) = = 3.06 ±0.02 µM).