Nickel(II) Complexes Based on Pyridyl- and Quinolyl-Containing Dialkylphosphine Oxides
摘要
The [Ni(L1)2(H2O)2](BF4)2(1-H2O) and [Ni(L2)2](BF4)2 (2) bis-chelate nickel(II) complexes based on 1,5-N,O-ligands, namely, (diisopropyl(pyridin-2-ylmethyl)phosphine oxide L1 and diisopropyl(quinolin-2-ylmethyl)phosphine oxide L2) are prepared. The structure and composition of 1-H2O and 2 are confirmed by mass spectroscopy, IR spectroscopy, thermogravimetric analysis, and elemental analysis. The compounds dissociate in solutions so that aqualigands in 1-H2O are replaced by acetonitrile to form the [Ni(L1)2(CH3CN)2](BF4)2(1-CH3CN) complex and phosphine oxide ligands in 2 are replaced by six water molecules to form the [Ni2(L2)4(H2O)12](BF4)2 hydrogen-bonded hexaaquanickel(II) agglomerate (3). The structure of 1-H2O, 1-CH3CN, and 3 in crystals are determined by XRD. Cytotoxic properties of the synthesized nickel(II) complexes against M-HeLa and HuTu80 cancer cells and normal Chang Liver cell lines are studied.