Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline

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发表日期：

2024年7月26日

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P. E. Savinykh,
Y. A. Golubeva,
K. S. Smirnova,
L. S. Klyushova,
M. P. Davydova,
A. V. Artemiev,
E. V. Lider

摘要

Abstract

The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]_n (1), [Cu(phen)(H₂O)L₂] (2), [Cu(dmphen)(H₂O)L₂] (3), [Cu(Cl-phen)(H₂O)L₂] (4), [Cu(bipy)(H₂O)L₂] (5). According to the XRD data, the phosphinate anion L^– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.