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Abstract <p>The serotonin transporter gene polymorphism influences theactivity of the serotonergic system, which plays a crucial rolein the regulation of mood, emotions, and behavior. 128-channel electroencephalograms(EEG) were recorded, and buccal epithelial samples were collectedfrom 41&#xa0;participants (24 females). The La-, Lg-, and S-alleles wereidentified using polymerase chain reaction. The aim of the studywas to identify patterns of emotional regulation of social behaviordepending on the serotonin transporter gene polymorphism by analyzingthe features of oscillatory dynamics and its localization duringperformance of a social choice task based on facial emotional stimuli.During EEG recording the emotional faces were presented, participantswere required to select one of three behavioral options: offer friendship,attack, or avoid interaction. Carriers of the SS-genotype selectedthe friendship with the character more frequently and avoid interaction lessoften, whereas LL-genotype carriers preferred to avoid interactionand rarely initiated friendship with the character. Equivalent currentdipole analysis revealed that S-allele carriers exhibited a morepronounced enhancement of theta rhythm in the left temporal cortex,that may be may associated with emotional processes. This is consistentwith research data indicating heightened emotional reactions inS-allele carriers. Furthermore, during avoidance of interaction,SS-genotype carriers demonstrated a greater decrease in alpha, mu,and beta rhythms in the left premotor, motor, somatosensory, andvisual cortical regions. This result may reflect an increase inarousal levels and engagement of cognitive processes for recognizingfacial emotional expressions and potentially understanding the character’sintentions, which is relevant for selecting further interaction.The study results indicate that the serotonin transporter gene polymorphismmay influence the choice of a specific type of interaction and theassociated neurophysiological processes.</p>

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Pilot Study of Association of Serotonin Transporter Gene Polymorphism (5-HTTLPR) with Oscillatory Responses during Social Choice Task Based on Facial Emotional Stimuli

  • 期刊论文

  • 发表日期：

    2026年6月21日

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  • A. V. Bocharov,
  • A. N. Savostyanov,
  • S. S. Tamozhnikov,
  • A. E. Saprygin,
  • D. A. Lebedkin,
  • G .G. Knyazev

摘要

Abstract

The serotonin transporter gene polymorphism influences theactivity of the serotonergic system, which plays a crucial rolein the regulation of mood, emotions, and behavior. 128-channel electroencephalograms(EEG) were recorded, and buccal epithelial samples were collectedfrom 41 participants (24 females). The La-, Lg-, and S-alleles wereidentified using polymerase chain reaction. The aim of the studywas to identify patterns of emotional regulation of social behaviordepending on the serotonin transporter gene polymorphism by analyzingthe features of oscillatory dynamics and its localization duringperformance of a social choice task based on facial emotional stimuli.During EEG recording the emotional faces were presented, participantswere required to select one of three behavioral options: offer friendship,attack, or avoid interaction. Carriers of the SS-genotype selectedthe friendship with the character more frequently and avoid interaction lessoften, whereas LL-genotype carriers preferred to avoid interactionand rarely initiated friendship with the character. Equivalent currentdipole analysis revealed that S-allele carriers exhibited a morepronounced enhancement of theta rhythm in the left temporal cortex,that may be may associated with emotional processes. This is consistentwith research data indicating heightened emotional reactions inS-allele carriers. Furthermore, during avoidance of interaction,SS-genotype carriers demonstrated a greater decrease in alpha, mu,and beta rhythms in the left premotor, motor, somatosensory, andvisual cortical regions. This result may reflect an increase inarousal levels and engagement of cognitive processes for recognizingfacial emotional expressions and potentially understanding the character’sintentions, which is relevant for selecting further interaction.The study results indicate that the serotonin transporter gene polymorphismmay influence the choice of a specific type of interaction and theassociated neurophysiological processes.