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Abstract <p>Bilateral symmetrical spike-and-wave discharges (SWDs) witha frequency of 7–11 Hz, recorded in WAG/Rij rats with geneticallydetermined absence activity, serve as electroencephalogram (EEG)hallmarks of this activity. Absence epilepsy proceeds without motormanifestations and is accompanied by freezing, and twitching ofthe vibrissae and head in rodents. Krushinsky-Molodkina (KM) ratstrain with a genetically determined predisposition to audiogenicepilepsy (AE) is considered a seizure model of reflex epilepsy.AE is characterized by the occurrence of tonic-clonic seizures provokedby an intense auditory stimulus. Approximately 20–50% of WAG/Rijrats exhibit a predisposition to AE, although with a less pronouncedaudiogenic seizure proneness compared to KM strain rats. Recentstudies of the electrical brain activity in KM rats have shown thepresence of absence-like activity on the EEG. This study aimed tocompare SWD characteristics in three groups of rats with varyingpredispositions to AE: (1) WAG/Rij-nonAGS (<i>n</i> =10)—WAG/Rij rats insensitive to a sound provocation, (2) WAG/Rij-AGS(<i>n</i> = 12)—WAG/Rij rats predisposedto AE, and (3) KM rats (<i>n</i> =18) with a maximum audiogenic seizure proneness. EEG recording wasperformed using bipolar electrodes implanted into the somatosensorycortex. A comparative analysis of spectral power, number, totaland average duration of SWDs was conducted in two subpopulationsof WAG/Rij rats (WAG/Rij-nonAGS, WAG/Rij-AGS) and KM rats with AEand absence-like EEG activity. Comparison between two subpopulationsof WAG/Rij rats showed a significant increase in the number, aswell as average and total duration, of SWDs in WAG/Rij-AGS comparedto WAG/Rij-nonAGS. SWDs in KM rats with a fundamental frequencyof 8.7 Hz were suppressed by ethosuximide and accompanied by behavioralsymptoms characteristic of absence epilepsy. Absence epilepsy exacerbatedin the following order: WAG/Rij-nonAGS → WAG/Rij-AGS → KM. Therefore,the severity of absence seizures increases in parallel with the enhancementof audiogenic brain reactivity, which may indicate the exacerbatingrole of the convulsive component in the structure of mixed epilepsy.</p>

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Spike-Wave Discharges in Two WAG/Rij Subpopulations and Krushinsky-Molodkina Rat Strain

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • S. M. Kuzhuget,
  • E. T. Tsyba,
  • N. M. Surina,
  • K. R. Abbasova

摘要

Abstract

Bilateral symmetrical spike-and-wave discharges (SWDs) witha frequency of 7–11 Hz, recorded in WAG/Rij rats with geneticallydetermined absence activity, serve as electroencephalogram (EEG)hallmarks of this activity. Absence epilepsy proceeds without motormanifestations and is accompanied by freezing, and twitching ofthe vibrissae and head in rodents. Krushinsky-Molodkina (KM) ratstrain with a genetically determined predisposition to audiogenicepilepsy (AE) is considered a seizure model of reflex epilepsy.AE is characterized by the occurrence of tonic-clonic seizures provokedby an intense auditory stimulus. Approximately 20–50% of WAG/Rijrats exhibit a predisposition to AE, although with a less pronouncedaudiogenic seizure proneness compared to KM strain rats. Recentstudies of the electrical brain activity in KM rats have shown thepresence of absence-like activity on the EEG. This study aimed tocompare SWD characteristics in three groups of rats with varyingpredispositions to AE: (1) WAG/Rij-nonAGS (n =10)—WAG/Rij rats insensitive to a sound provocation, (2) WAG/Rij-AGS(n = 12)—WAG/Rij rats predisposedto AE, and (3) KM rats (n =18) with a maximum audiogenic seizure proneness. EEG recording wasperformed using bipolar electrodes implanted into the somatosensorycortex. A comparative analysis of spectral power, number, totaland average duration of SWDs was conducted in two subpopulationsof WAG/Rij rats (WAG/Rij-nonAGS, WAG/Rij-AGS) and KM rats with AEand absence-like EEG activity. Comparison between two subpopulationsof WAG/Rij rats showed a significant increase in the number, aswell as average and total duration, of SWDs in WAG/Rij-AGS comparedto WAG/Rij-nonAGS. SWDs in KM rats with a fundamental frequencyof 8.7 Hz were suppressed by ethosuximide and accompanied by behavioralsymptoms characteristic of absence epilepsy. Absence epilepsy exacerbatedin the following order: WAG/Rij-nonAGS → WAG/Rij-AGS → KM. Therefore,the severity of absence seizures increases in parallel with the enhancementof audiogenic brain reactivity, which may indicate the exacerbatingrole of the convulsive component in the structure of mixed epilepsy.