Scholarlink

Abstract <p>Research into neuroprotective strategies aimed at correctingdiet- and aging-related hippocampal dysfunction is of high relevancegiven the increasing prevalence of the Western diet and global population aging.This study investigated the effects of a long-term high-fat diet(HFD) and the antioxidant astaxanthin (AST) on the hippocampal stateduring aging in mice. Aging was shown to be accompanied by the impairmentof long-term memory and the development of chronic neuroinflammationin the hippocampus. HFD had a moderate effect on hippocampal alterationscompared to animals fed a standard diet (SD). The age-related dynamicsof microglial activity, assessed by Iba1 immunoreactivity, was characterizedby its increase in the hippocampal CA1 and CA3 regions and dentategyrus (DG) at 12 months, followed by a decrease at 15 months. DietaryAST supplementation led to improved passive avoidance performanceand exerted a duration-dependent effect: when administered for lessthan 6 months, AST promoted the suppression of pro-inflammatoryactivity, as evidenced by the downregulation of NF-κB expressionin the hippocampus. However, longer continuous AST administration,conversely, led to the upregulation of NF-κB expression. These resultsindicate the ambiguous effects of HFD on the brain and emphasizethe importance of optimizing the timing of antioxidant administrationfor protecting the hippocampus from neuroinflammation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of Astaxanthin on Hippocampal Neuroinflammation in Aging Mice Fed a High-Fat Diet

  • 期刊论文

  • 发表日期：

    2026年2月26日

查看全文
  • E. V. Fedorova,
  • D. A. Fedorov,
  • I. Yu. Chernomorets,
  • А. S. Galashin,
  • V. I. Arkhipov

摘要

Abstract

Research into neuroprotective strategies aimed at correctingdiet- and aging-related hippocampal dysfunction is of high relevancegiven the increasing prevalence of the Western diet and global population aging.This study investigated the effects of a long-term high-fat diet(HFD) and the antioxidant astaxanthin (AST) on the hippocampal stateduring aging in mice. Aging was shown to be accompanied by the impairmentof long-term memory and the development of chronic neuroinflammationin the hippocampus. HFD had a moderate effect on hippocampal alterationscompared to animals fed a standard diet (SD). The age-related dynamicsof microglial activity, assessed by Iba1 immunoreactivity, was characterizedby its increase in the hippocampal CA1 and CA3 regions and dentategyrus (DG) at 12 months, followed by a decrease at 15 months. DietaryAST supplementation led to improved passive avoidance performanceand exerted a duration-dependent effect: when administered for lessthan 6 months, AST promoted the suppression of pro-inflammatoryactivity, as evidenced by the downregulation of NF-κB expressionin the hippocampus. However, longer continuous AST administration,conversely, led to the upregulation of NF-κB expression. These resultsindicate the ambiguous effects of HFD on the brain and emphasizethe importance of optimizing the timing of antioxidant administrationfor protecting the hippocampus from neuroinflammation.